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KMID : 0363620100310060001
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Journal of Korean Oriental Medicine
2010 Volume.31 No. 6 p.1 ~ p.7
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Effect of Galhwahyejung-tang (GHT) on Alcohol-induced Oxidative Stress in Rats
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Kim Dong-Gyu
Kim Tae-Hwan
Park Sang-Eun
Kim Hyung-Geug
Son Chang-Gue
Hong Sang-Hoon
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Abstract
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Objectives: This study was aimed to investigate the effects of Galhwahyejung-tang (GHT) on alcohol-induced oxidative stress in rat model.
Methods: Twenty SD rats were orally administrated with 40% ethanol (mL/kg) combined with GHT (50, 100, 200mg/kg) or distilled water for 2 weeks. Biochemistry in blood, malondialdehyde (MDA), total reactive oxygen species (ROS), and total antioxidant capacity (TAC) in serum, liver, brain, and kidney were determined.
Results: GHT treatment significantly ameliorated the alcohol-induced alteration of hepatic enzyme; especially AST and ALT. GHT treatment also ameliorated the increase of MDA in liver, ROS level in serum and brain. GHT treatment reduced the depletion of antioxidant capacity in serum and brain.
Conclusion: These results that GHT has antioxidant properties explaining the relevance of clinical application and its partial mechanisms of GHT.
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KEYWORD
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Alcohol, oxidative stress, Galhwahyejung-tang, traditional Korean medicine
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